Women’s Health Initiative (WHI)
The large 2002 trial whose early results led many women and doctors to stop hormone therapy. Later analyses showed risks depend heavily on age and time since menopause.
Rossouw JE, et al. JAMA. 2002;288(3):321–333.
Studies & Guides
Free guides to bring to your next appointment, and the research behind our approach, summarized in plain language.

Guides
Print them, fill them in, and bring them to your visit.
Our free guide to the symptom patterns most often missed in midlife, sent straight to your inbox.
Track what you feel for a week so patterns are easier to spot and explain.
Open & printWhat to bring and what to ask, so you leave your appointment with real answers.
Open & printMark each day: ✓ if present, or rate 0 (none) to 10 (severe). Name: ____________________ Week of: __________
| Symptom | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| Hot flashes / night sweats | |||||||
| Sleep quality (0–10) | |||||||
| Mood / anxiety (0–10) | |||||||
| Energy (0–10) | |||||||
| Brain fog | |||||||
| Joint or muscle aches | |||||||
| Period / bleeding | |||||||
| Other |
Notes (triggers, medications, what helped):
Bring this to your next appointment.
Bring with you
Questions to ask
Studies
Key studies and guidelines, summarized in plain language. Follow the links to read the originals.
The large 2002 trial whose early results led many women and doctors to stop hormone therapy. Later analyses showed risks depend heavily on age and time since menopause.
Rossouw JE, et al. JAMA. 2002;288(3):321–333.
Eighteen years of follow-up found hormone therapy was not associated with increased all-cause mortality among women in the WHI trials.
Manson JE, et al. JAMA. 2017;318(10):927–938.
The Menopause Society (formerly NAMS) concludes that for healthy women under 60, or within 10 years of menopause, the benefits of hormone therapy generally outweigh the risks for bothersome symptoms.
The North American Menopause Society. Menopause. 2022;29(7):767–794.
Reviews the evidence for non-hormonal options for hot flashes, including prescription medications and behavioral approaches, for women who can’t or prefer not to use hormones.
The North American Menopause Society. Menopause. 2023;30(6):573–590.
Among women with frequent hot flashes and night sweats, symptoms lasted a median of 7.4 years, and persisted a median of 4.5 years after the final period.
Avis NE, et al. JAMA Intern Med. 2015;175(4):531–539.
In a 2019 study of 183 family medicine, internal medicine, and OB/GYN residents across 20 training programs, only 6.8% felt adequately prepared to manage menopause, and one in five had received no menopause lectures.
Kling JM, et al. Mayo Clin Proc. 2019;94(2):242–253.
These summaries are educational and not medical advice. Talk with a clinician about what applies to you.
Bring your questions to a clinician who looks at the whole picture.